Acute generalized exanthematous pustulosis - O'Tkir Umumiy Ekzantematoz Pustuloz
O'Tkir Umumiy Ekzantematoz Pustuloz (Acute generalized exanthematous pustulosis) (AGEP) kam uchraydigan teri reaktsiyasi bo'lib, 90% hollarda dori-darmonlarni qabul qilish bilan bog'liq. o'tkir umumiy ekzantematoz pustuloz (acute generalized exanthematous pustulosis) preparat boshlanganidan keyin o'rtacha besh kun o'tgach paydo bo'ladigan to'satdan teri portlashlari bilan tavsiflanadi. Bu portlashlar pustulalar, ya'ni loyqa yoki yiringli material (yiring) o'z ichiga olgan terining kichik qizil oq yoki qizil chiqishi. Teri lezyonlari odatda dori-darmonlarni qabul qilishni to'xtatgandan keyin 1-3 kun ichida yo'qoladi.
☆ Germaniyaning 2022 yilgi Stiftung Warentest natijalariga ko'ra, iste'molchilarning ModelDermdan qoniqish darajasi pullik teletibbiyot maslahatlariga qaraganda bir oz pastroq bo'lgan.
Eritema va pustulalar bilan keng tarqalgan lezyonlar birdan paydo bo'ladi.
References
Acute generalized exanthematous pustulosis (AGEP) - qizil teri tagida mayda, yiringli bo'shliqlar bilan ifodalangan teri reaktsiyasi. Odatda, kimdir antibiotiklar kabi ba'zi dori-darmonlarni qabul qilganda va tezda tanaga tarqalib ketganda sodir bo'ladi. Tetiklantiruvchi dori-darmonlarni qabul qilishni to'xtatgandan so'ng, semptomlar odatda ikki hafta ichida yo'qoladi va ko'pincha terining biroz to'kilishini qoldiradi. Odatda jiddiy bo'lmasa va teri bilan cheklangan bo'lsa ham, og'ir holatlar boshqa jiddiy teri reaktsiyalari bilan bir qatorda Stevens-Johnson syndrome yoki toxic epidermal necrolysis kabi tasniflanishi mumkin. Davolash birinchi navbatda qo'llab-quvvatlovchi yordamdir va kasallikning to'liq hal qilish prognozi odatda juda yaxshi.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
76 yoshli erkak tez yordam bo'limiga so'nggi ikki kun ichida terisi o'zgarganligi sababli keldi. Shifokorlar uning tanasida, qo'llari va oyoqlarida qizil dog'lar va ko'tarilgan joylarni topdilar. Vaqt o'tishi bilan bu yamalar bir-biriga qo'shildi va u qizil joylarda pimple o'xshash bo'shliqlar paydo bo'ldi. Sinovlar neytrofillar deb ataladigan ko'plab turdagi oq qon hujayralari sonining yuqoriligini va C-reactive protein darajasini ko'rsatdi.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
